Associate Professor Evan Ingley
The Harry Perkins Institute of Medical Research.
Associate Professor Evan Ingley heads the Cell Signalling Group at the Harry Perkins Institute of Medical Research, which has an interest in understanding the signalling networks or “information highways” of both normal and diseased cells. Many of the new generation anti-cancer/leukaemia drugs, such as tyrosine kinase inhibitors (TKIs, e.g. Dasatinib) disrupt these signalling networks and bring about a “normalization” of protein interactions. One of the underlying control principles of these processes is that of regulated protein-protein interactions. A/Prof Ingley’s group focuses on an enzyme, called Lyn, which is a tyrosine kinase that modifies proteins and through this process mediates specific protein interactions that regulate particular cancer cell processes including growth, invasion, metastasis, differentiation and death.
What funding from SitS means to me:
We have discovered a pathway that controls invasion and metastasis of sarcoma cells in the laboratory, centred on a novel molecule called AFAP1L1, and this pathway is highly expressed in malignant/metastatic forms of human sarcoma. The opportunity now exists through funding from Sock it to Sarcoma to test our hypothesis that this new pathway is a potential molecular target for sarcoma invasion/metastasis in preclinical animal models of malignant/metastatic sarcoma.
Andrea is a current Associate Lecturer at the School of Psychology and Exercise Science at Murdoch University. Andrea’s background is in organisational psychology, having completed her Masters in Industrial/Organisational Psychology at the UWA Psychology department, and about to submit her PhD in Strategic Management from the UWA Business School. Andrea has tutored and lectured undergraduate and postgraduate management units at the UWA Business School and Curtin Business School and is currently coordinating a first year psychology unit at Murdoch, as well as acting as Psychology offshore course coordinator for all psychology units run out of the Murdoch Singapore campus. Andrea is also active in supervising research students.
Andrea has given several research based presentations at various leading academic and industry conferences, both nationally and internationally, including the Society for Industrial/Organizational Psychology (SIOP) and the International Congress of Applied Psychology (ICAP), as well as chairing multiple symposia at these conferences. Andrea brings to the project consulting experience from both big and small business.
Andrea is interested in organizationally-based applied research, and sees the Time4Me project as a valuable way to use her expertise to contribute to the literature on increasing wellbeing, whilst adding value to the lives of cancer sufferers and their families.
Ms Claire Munsie
School of Sport Science, Exercise and Health and the School of Surgery, University of Western Australia
Claire is an accredited exercise physiologist at Hollywood Functional Rehabilitation Clinic where she has worked since graduating from UWA in 2008. At HFRC Claire specialises in pre and post-operative exercise rehabilitation programs and musculo-skeletal rehabilitation. It was here at HFRC she was first introduced to Professor David Wood and the fantastic work he is doing with Sarcoma patients, and Sock it to Sarcoma!. This sparked her interest to become involved and is now undertaking her Masters in Exercise Physiology at UWA. Her research program investigates the long term functional deficits associated with wide resection surgery and how exercise rehabilitation can improve these functional problems. Claire is now involved with yearly fundraising for Sock it to Sarcoma! through participation in the Ride to Conquer cancer in 2013 and 2014.
Funding through the Emma Pauley Research grant will allow Claire to complete her MSc and will assist with providing a basis to develop an exercise rehabilitation program to be implemented into hospital systems across Australia. This will allow individuals currently going through Sarcoma treatment to access exercise based therapy during their recovery.